MOLECULAR ONCOLOGY
MYB–MuvB activation of mitotic genes

Research programme 03

MYB–MuvB activation of mitotic genes

We study how B-MYB, A-MYB and FOXM1 engage the MuvB core to activate genes required for G2, mitosis and successful cell division.

Central question

Which transcription-factor substitutions preserve cell-cycle progression when the canonical B-MYB programme is disrupted?

MuvB switches partners as cells move from quiescence into proliferation. In DREAM it supports repression; in MMB and related complexes it recruits MYB-family activators and FOXM1 to CHR-containing promoters.

Model of DREAM-to-MYB/MuvB-to-FOXM1/MuvB complex switching across the cell cycle. Figure 9 from Uxa et al., Cell Death & Differentiation (2021), “Ki-67 gene expression.” Reused under CC BY 4.0.
Model of DREAM-to-MYB/MuvB-to-FOXM1/MuvB complex switching across the cell cycle. Figure 9 from Uxa et al., Cell Death & Differentiation (2021), “Ki-67 gene expression.” Reused under CC BY 4.0.

Approaches

MYB-family knockdown and rescueMuvB interaction assaysCell-cycle transcriptomics

Selected work

A-MYB substitutes for B-MYB in activating cell cycle genes and in stimulating proliferation (2024)
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